Transient receptor potential canonical 3 channel (TRPC3)

Transient receptor potential canonical 3 channel (TRPC3) is a member of the transient receptor potential (TRP) channel family and functions as a nonselective, Ca^2+-permeable cation channel. It is broadly expressed in various tissues including brain, heart, endocrine glands, and smooth muscle, and is crucial for cellular calcium signaling. TRPC3 is directly activated by diacylglycerol downstream of G protein-coupled receptor activation and regulated by endogenous lipids, Ca^2+ ions, and protein interactions. Its physiological roles include mediation of store-operated and receptor-operated calcium entry, mitochondrial Ca^2+ uptake regulation, and protein scaffolding at the plasma membrane. TRPC3 is implicated in several pathologies, notably cardiovascular diseases (such as hypertension and cardiac fibrosis), neurodegenerative diseases, cancer, and inflammation, making it a significant therapeutic target[2][4][5][6][7][3][1].

Other names

TRPC3TRP-3Transient receptor potential cation channel subfamily C member 3

Channel blockers or modulators alter calcium influx by inhibiting or activating TRPC3-mediated cation flow; Antagonists prevent activation by endogenous lipids or diacylglycerol