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Target intelligence / Profile preview
Transient Receptor Potential Canonical 4 (TRPC4)
- Target
- TRPC4
- Molecular classification
- Ion channel, TRP channel, Non-selective cation channel
01
Overview
Transient receptor potential canonical 4 (TRPC4) is a non-selective cation channel that belongs to the canonical subfamily of transient receptor potential (TRP) channels. It plays crucial roles in various physiological processes, particularly in calcium signaling pathways. TRPC4 is expressed in various tissues and cell types, including brain regions, intestinal cells of Cajal, adrenal glands, kidneys, smooth muscle cells and endothelial cells. It contributes to phospholipase C-dependent Ca²⁺ entry into cells following stimulation of G protein-coupled receptors and receptor tyrosine kinases. TRPC4 has been implicated in cardiovascular and neurological disorders and could potentially serve as a therapeutic target.
02
Mechanism of action
Modulation of TRPC4 channel activity
03
Biological functions
Calcium signalingRegulation of neuronal excitabilityRegulation of smooth muscle excitabilityVascular regulationRegulation of pulmonary microvascular permeabilityStore-operated calcium entry (SOCE)
04
Disease associations
Cardiovascular diseasesCardiac hypertrophyArrhythmiasMyocardial infarctionAtrial fibrillationNeurological disorders
05
Safety considerations
Potential for off-target effects due to TRPC4's wide expression and involvement in multiple physiological processes.Further investigation needed to understand the specific roles of TRPC4 in different neurological conditions.
06
Interacting drugs
Small molecular modulators of TRPC4 channels
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