Transient receptor potential canonical channel 5 (TRPC5)

Transient receptor potential canonical channel 5 (TRPC5) is a calcium-permeable, non-selective cation channel that forms part of the larger TRP channel superfamily. It is primarily expressed in the central nervous system but found also in peripheral tissues such as the kidney, vasculature, and sensory neurons. TRPC5 channels can form homo- or heterotetrameric complexes (with TRPC1 or TRPC4), are activated by G protein-coupled receptor signaling, membrane stretch, cold, and various intracellular and extracellular stimuli (e.g., phospholipase C, nitric oxide, lysophospholipids). The channel contributes to calcium signaling, neuronal excitability, vascular tone regulation, and sensory processes including innocuous cold sensing. TRPC5 has been implicated in several physiological and pathological processes such as anxiety, seizure susceptibility, and vascular dysfunction. Pharmacologically, the channel is targetable by anesthetics, and small-molecule inhibitors are being studied for their potential utility in neurological and cardiovascular diseases.

Other names

TRPC5Short transient receptor potential channel 5Transient receptor protein 5TRP-5

Modulation of calcium influx via channel inhibition or activation; Alteration of membrane excitability (by influencing Ca²⁺ and Na⁺ permeability); Receptor-operated channel gating (via G protein-coupled receptor signaling)