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Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6)

Target: TRPC6
Molecular classification: Ion channel, Transient Receptor Potential (TRP) superfamily, TRPC subfamily, Nonselective cation channel

Overview

TRPC6 is a nonselective cation channel belonging to the TRP superfamily. It is activated by diacylglycerol and mechanical stretch, playing critical roles in regulating vascular tone, podocyte function in the kidney, and neuronal signaling. Its dysfunction is implicated in kidney diseases like FSGS, pulmonary hypertension, and cardiac hypertrophy, making it a potential therapeutic target.

Other names: TRP6Transient receptor potential channel 6

Mechanism of action

Activation by diacylglycerol binding or mechanical stretch, leading to cation influx (primarily calcium)

Biological functions

Ion transportCalcium signalingRegulation of vascular tonePodocyte functionNeuronal signalingMechanotransduction

Disease associations

Kidney disease (FSGS, nephrotic syndrome)Pulmonary hypertensionCardiac hypertrophyNeurological disorders

Safety considerations

Potential for off-target effects due to homology with other TRP channelsComplex role in multiple physiological processes, making it difficult to predict systemic effects of modulationAberrant activation can lead to severe kidney diseasePotential for dysregulation of calcium homeostasis

Interacting drugs

Small molecule antagonists of TRPC6

1 more in the full profile.

Biomarkers

TRPC6 expression levels in kidney biopsies (for FSGS diagnosis)Levels of TRPC6 modulating antibodies in kidney disease

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