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Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7)
- Target
- TRPM7
- Molecular classification
- Ion channel, TRP channel, Nonselective cation channel, Serine/threonine kinase, Enzyme
01
Overview
TRPM7 is a unique bifunctional protein combining an ion channel with an intrinsic serine/threonine kinase. It functions as a nonselective cation channel permeable to Mg²⁺, Zn²⁺, and Ca²⁺, and its kinase domain modulates various signaling pathways. TRPM7 plays essential roles in embryonic development, divalent cation balance, immune responses, cell mobility, proliferation, differentiation, and neuronal/cardiovascular function. Dysregulation is implicated in hypomagnesemia, seizures, developmental delay, cancer, neuronal disorders, cardiovascular diseases, and immune dysfunctions, making it a potential drug target.
02
Mechanism of action
Modulation of ion channel activity and kinase signaling pathways.
03
Biological functions
Ion transportMagnesium homeostasisZinc homeostasisCalcium homeostasisCell mobilityCell proliferationCell differentiationEmbryonic developmentImmune responseNeuronal functionCardiovascular functionPhosphorylation
04
Disease associations
HypomagnesemiaSeizuresDevelopmental delayCancerNeuronal disordersCardiovascular diseasesImmune system dysfunctions
05
Safety considerations
Potential for dysregulation of magnesium and other divalent cation homeostasis.Off-target effects due to ubiquitous expression.
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