Transient receptor potential cation channel subfamily A member 1 and Transient receptor potential cation channel subfamily M member 8 (TRPA1/TRPM8)

Transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential melastatin 8 (TRPM8) are non-selective cation channels belonging to the TRP superfamily, primarily expressed in sensory neurons of the dorsal root and trigeminal ganglia (UniProt O75762, Q7Z2W7). TRPA1 acts as a 'chemosensor' activated by pungent compounds like allyl isothiocyanate and environmental irritants, playing a critical role in inflammatory pain and respiratory irritation (PubMed 30114470). TRPM8 is the primary molecular transducer of innocuous cold and is activated by cooling agents such as menthol (PubMed 24132514). Both channels are significant therapeutic targets because of their involvement in various pain states, including neuropathic and inflammatory pain, as well as respiratory conditions like chronic cough and asthma (PubMed 25109461). Pharmacological modulation of these channels, particularly through antagonism, aims to alleviate hypersensitivity and pain, though challenges remain regarding thermoregulatory side effects and target specificity (PubMed 28130410). This entry is marked as incorrect because it combines two distinct protein targets into a single record, although they are frequently co-studied in the context of sensory pharmacology.

Other names

ANKTM1CMR1LMR1TRP-A1TRP-M8Cold and menthol receptor 1Transient receptor potential ankyrin 1Transient receptor potential melastatin 8

Modulation (antagonism or agonism) of non-selective cation channels to regulate the influx of calcium and sodium ions, thereby altering the membrane potential and excitability of sensory neurons.