Transient receptor potential cation channel subfamily C member 1 and Transient receptor potential cation channel subfamily C member 6 (TRPC1/TRPC6)

Transient receptor potential canonical channels 1 and 6 (TRPC1 and TRPC6) are non-selective cation channels that play a pivotal role in cellular calcium homeostasis and signaling. These channels are part of the TRPC subfamily and are known to form both homomeric and heteromeric complexes on the plasma membrane (Tang et al., 2018; MDPI, 2020). TRPC6 is primarily a receptor-operated channel activated by diacylglycerol (DAG) downstream of phospholipase C (PLC) signaling, whereas TRPC1 is frequently associated with store-operated calcium entry (SOCE) in coordination with STIM1 and Orai1 (NIH, 2020; NIH, 2021). In pathological states, TRPC6 overactivation is a well-established driver of focal segmental glomerulosclerosis (FSGS) and diabetic nephropathy, leading to podocyte injury and proteinuria (NIH, 2021; NIH, 2026). Furthermore, TRPC1 and TRPC6 are implicated in the pathogenesis of pulmonary arterial hypertension and cardiac hypertrophy through their regulation of vascular and cardiac smooth muscle cell proliferation and contraction (NIH, 2020; NIH, 2021). Pharmacological targeting of these channels, particularly with selective TRPC6 inhibitors like BI 764198 and GFB-887, is currently being explored as a therapeutic strategy to treat chronic kidney diseases and cardiovascular disorders (NIH, 2020; ResearchGate, 2020).

Other names

TRPC1TRPC6TRP-C1TRP-C6Transient receptor potential channel 1Transient receptor potential channel 6CCE1TRP1FSGS2Transient receptor potential canonical channels TRPC1/TRPC6

Inhibition of non-selective cation influx, specifically blocking calcium and sodium entry mediated by diacylglycerol or store-depletion signals (NIH, 2020; NIH, 2021).