Transient receptor potential cation channel subfamily C member 3 (TRPC3)

Transient receptor potential cation channel subfamily C member 3 (TRPC3) is a receptor-activated, non-selective cation channel highly permeable to calcium and other cations[5][6][8]. It is part of the canonical TRP (TRPC) channel family and is activated by second messengers such as diacylglycerol, often following stimulation of receptor tyrosine kinases or G protein-coupled receptors[5][6]. TRPC3 regulates intracellular calcium levels and contributes to processes such as neuronal excitability, cell proliferation, vascular tone regulation, and cardiac rhythmicity[5][6][3]. Genetic mutations in TRPC3 are linked to neurodegenerative disorders, including spinocerebellar ataxia 41, and alterations in its function are implicated in memory loss, cardiac arrhythmias, and hypertension[7][6]. Structurally, TRPC3 forms a tetramer with distinct cytoplasmic and transmembrane domains, exhibiting a unique fold within the TRP channel superfamily[4][1][3]. Its pharmacological modulation is under investigation as a therapeutic strategy for cardiovascular and neurological disorders[2][4][7].

Other names

Short transient receptor potential channel 3Transient receptor protein 3TRP-3TRP3TRPC3_HUMAN

Inhibition of channel gating via allosteric interaction (BTDM wedges between domains to inhibit opening) - Activation via lipid second messengers (e.g. diacylglycerol, OAG) - Modulation through phosphatidylinositol pathways and receptor tyrosine kinase or G-protein coupled receptor signaling