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Target intelligence / Profile preview
Transient receptor potential cation channel subfamily C member 4 (TRPC4)
- Target
- TRPC4
- Molecular classification
- Ion channel, TRP channel, Cation channel
01
Overview
Transient receptor potential cation channel subfamily C member 4 (TRPC4) is a non-selective, calcium-permeable cation channel involved in various physiological processes. It is activated by Gαi-coupled receptors, Gαq-coupled receptors, and tyrosine kinases, playing roles in endothelial permeability, vasodilation, neurotransmitter release, and cell proliferation. TRPC4 is highly expressed in cortico-limbic regions of the brain and endothelial cells. Its dysregulation is implicated in several diseases, including pulmonary hypertension, cardiac hypertrophy and seizure susceptibility. The channel is regulated by endogenous proteins such as calmodulin and can be modulated by small molecule inhibitors like GFB compounds.
- Other names
- HTRP-4HTRP4TRP4
02
Mechanism of action
Inhibition of TRPC4 channel activity
03
Biological functions
Ion transportCalcium signalingRegulation of endothelial permeabilityVasodilationNeurotransmitter releaseCell proliferation
04
Disease associations
Pulmonary hypertensionCardiac hypertrophyPodocyte injurySeizure susceptibilityFear responseGastrointestinal motility disorders
05
Interacting drugs
GFB compounds
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