Transient receptor potential cation channel subfamily C member 4 associated protein (TRPC4AP)

Transient receptor potential cation channel subfamily C member 4 associated protein (TRPC4AP) is a human protein encoded by the *TRPC4AP* gene. It functions primarily as a substrate-specific adaptor in the DDB1-CUL4-X-box (DCX) E3 ubiquitin ligase complex, where it mediates the polyubiquitination and subsequent degradation of proteins such as MYC by recognizing C-terminal degron motifs. TRPC4AP is also involved in the ubiquitin-dependent protein catabolic process, cell cycle regulation, and may contribute to the activation of signaling pathways downstream of the tumor necrosis factor receptor (TNFRSF1A), including NF-κB and c-Jun N-terminal kinase via its interaction with TRAF2. It is expressed ubiquitously in human tissues and shows altered expression in certain disease states, such as Alzheimer’s disease and cancer. There are currently no approved drugs targeting TRPC4AP, nor is it considered a direct therapeutic target.

Other names

Short transient receptor potential channel 4-associated proteinTrpc4-associated proteinTRRP4APC20orf188PPP1R158Protein TAP1Protein TRUSSTumor necrosis factor receptor-associated ubiquitous scaffolding and signaling proteinTNF-receptor ubiquitous scaffolding/singaling proteinDKFZp586C1223DKFZP727M231dJ756N5.2Chromosome 20 open reading frame 188Trp4-associated proteinProtein phosphatase 1, regulatory subunit 158