Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Transient receptor potential cation channel subfamily C member 5 (TRPC5)
- Target
- TRPC5
- Molecular classification
- Ion channel, Transient Receptor Potential Canonical (TRP-C)
01
Overview
Transient receptor potential cation channel subfamily C member 5 (TRPC5) is a non-selective, calcium-permeant cation channel involved in various physiological processes including cold sensing, pain modulation, and store-operated calcium entry. It is a promising drug target for progressive kidney disease, depression, anxiety disorders, and pain. TRPC5 can form homotetramers or heteromultimers with other TRPC proteins. Its activity is modulated by extracellular reduced thioredoxin, certain anesthetics, and lysophosphatidylcholine (LPC).
- Other names
- Short transient receptor potential channel 5TrpC5
02
Mechanism of action
Inhibition of TRPC5 channel activity by stabilizing the channel in a closed state.
03
Biological functions
Calcium signalingCold sensationPain modulationStore-operated calcium entry
04
Disease associations
Kidney diseaseDepressionAnxietyPain hypersensitivityNeuropathic painInflammatory pain
05
Interacting drugs
Clemizole
4 more in the full profile.
Beyond the preview
Go deeper on Transient receptor potential cation channel subfamily C member 5 (TRPC5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Transient receptor potential cation channel subfamily C member 5 (TRPC5).