Transient receptor potential cation channel subfamily M member 1 (TRPM1)

Transient receptor potential cation channel subfamily M member 1 (TRPM1) is a non-selective cation channel predominantly expressed in retinal ON bipolar cells and melanocytes. In the retina, it is essential for the transmission of visual signals from rod photoreceptors under low-light conditions and plays a crucial role in the ON visual pathway through signal transduction downstream of metabotropic glutamate receptor 6 (mGluR6)[1][2][3][4]. In melanocytes, TRPM1 is associated with regulating melanin synthesis and pigmentation[1][2][3]. Mutations in the TRPM1 gene commonly result in autosomal recessive congenital stationary night blindness, manifesting as impaired vision in low-light environments. TRPM1 has also been implicated in pigmentation disorders and, indirectly, in melanoma progression via a co-expressed microRNA, though the protein itself is not regarded as a tumor suppressor[3]. Currently, there are no drugs that directly target TRPM1 for therapeutic purposes.

Other names

Long transient receptor potential channel 1LTRPC1Melastatin-1MLSN1Transient receptor potential cation channel, subfamily M, member 1Transient receptor potential melastatin familyTRPM1_HUMAN[2][3]

Not specifically targeted by approved drugs Channel activity may be modulated indirectly by the signaling cascade (e.g., metabotropic glutamate receptor 6 [mGluR6] in retina), influencing the closing/opening of the channel in response to neurotransmitters[3][4]