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Target intelligence / Profile preview
Transient Receptor Potential Cation Channel Subfamily M Member 7 (TRPM7)
- Target
- TRPM7
- Molecular classification
- Ion channel, Kinase, Serine/threonine kinase
01
Overview
TRPM7 is a bifunctional protein combining an ion channel with a serine/threonine kinase domain. It functions as a nonselective cation channel permeable to Mg²⁺, Zn²⁺, and Ca²⁺, regulating cellular uptake of these ions. It also possesses intrinsic kinase activity, phosphorylating itself and other substrates involved in cytoskeletal regulation and signaling pathways. TRPM7 is essential for embryonic development and plays a role in cell motility, adhesion, migration, polarization, proliferation, and survival. Aberrant TRPM7 expression is linked to cancer progression and metastasis, and it modulates platelet reactivity, affecting thrombosis and stroke risk.
02
Biological functions
Ion homeostasis (Mg/Zn/Ca)Cation transportProtein phosphorylationCell motilityCell migrationCell polarizationCell adhesionCell proliferationCell survival
03
Disease associations
CancerThrombosisStroke
04
Safety considerations
Embryonic lethality if completely knocked outPotential impact on essential cellular processes due to ubiquitous expression
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