Target intelligence / Profile preview

Transient Receptor Potential Cation Channel Subfamily M Member 8 (TRPM8)

Target: TRPM8
Molecular classification: Ion channel, TRP channel, Receptor

Overview

TRPM8 is a non-selective, voltage-dependent cation channel primarily known as the molecular sensor for cold temperatures and cooling agents like menthol. It is expressed in sensory neurons and other tissues, playing a role in thermosensation and potentially in cellular homeostasis through calcium signaling and regulation of autophagy. It is a target for analgesic drug development.

Mechanism of action

Activation by cold or chemical ligands (menthol, icilin) opens the channel, leading to Na+ and Ca2+ influx, depolarization, and action potential generation. Antagonists (AMTB) block this activation.

Biological functions

Somatosensory perceptionThermosensationCalcium signalingRegulation of autophagy

Disease associations

Pain perceptionCancer (e.g., prostate cancer)

Interacting drugs

Menthol

4 more in the full profile.

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