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Target intelligence / Profile preview
Transient Receptor Potential Cation Channel Subfamily V Member 2 (TRPV2)
- Target
- TRPV2
- Molecular classification
- Ion channel, TRP channel, Receptor
01
Overview
Transient receptor potential cation channel subfamily V member 2 (TRPV2) is a non-selective cation channel that is permeable to calcium and other cations. It plays key roles in cellular signaling and physiological responses, including mediating cellular responses to noxious heat (>52°C) and regulating immune cell activities such as cytokine secretion and phagocytosis via Ca²⁺ signaling. Activation can occur via high temperature, mechanical stimuli, and ligands including IGF‑1, PDGF, and neuropeptides. TRPV2 is a potential target for therapeutic intervention across inflammatory diseases and cancer microenvironments.
- Other names
- VRLVRL-1VRL1
02
Mechanism of action
Modulation of calcium influx and cellular signaling
03
Biological functions
Ion transportCalcium signalingThermosensationMechanosensationImmune response regulationCytokine releasePhagocytosisPodosome assembly
04
Disease associations
Inflammatory diseasesCancer
05
Safety considerations
Potential for off-target effects due to broad cation permeabilityModulation of pain perception
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