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Target intelligence / Profile preview
Transient Receptor Potential Cation Channel Subfamily V Member 3 (None)
- Target
- None
- Molecular classification
- Ion channel, Nonselective cation channel, TRP channel, TRPV subfamily
01
Overview
Transient Receptor Potential Cation Channel Subfamily V Member 3 (TRPV3) is a nonselective cation channel that plays key roles in temperature sensation, skin physiology, and various cellular processes. It is activated by warm temperatures and certain chemical agonists, and is primarily expressed in keratinocytes and sensory neurons. Dysregulation of TRPV3 has been linked to skin disorders like Olmsted Syndrome and Palmoplantar keratoderma.
02
Mechanism of action
Modulation of TRPV3 channel activity
03
Biological functions
Temperature sensationPain perceptionSkin homeostasisHair developmentEpidermal barrier formationWound healingVasoregulationIon channel transportCREB signaling pathway
04
Disease associations
Olmsted Syndrome type IPalmoplantar keratoderma (nonepidermolytic focal type)
05
Interacting drugs
2-Aminoethoxydiphenyl borate (2-APB)
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