Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4)
- Target
- TRPV4
- Molecular classification
- Ion channel, Receptor
01
Overview
TRPV4 is a Ca²⁺-permeable, nonselective cation channel involved in various physiological processes. It functions as a multifunctional cellular sensor activated by osmotic changes, mechanical stimuli, chemical ligands, and thermal changes. Dysregulation of TRPV4 is linked to skeletal dysplasias, neuropathies, and other diseases.
02
Mechanism of action
Channel activation or inhibition (depending on the drug)
03
Biological functions
OsmoregulationVascular regulationSkin barrier maintenanceSkeletal growth and integrityAirway/lung function regulationPain sensation
04
Disease associations
Skeletal dysplasiasNeuropathiesEdemaCharcot-Marie-Tooth diseaseMetatropic dysplasiaArthropathy
05
Safety considerations
Potential for edema formation after injury/inflammationVaried disease associations with mutations
06
Interacting drugs
4α-PDD
1 more in the full profile.
Beyond the preview
Go deeper on Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4).