Transient receptor potential channel 2 (TRP-2)

Transient receptor potential channel 2 (TRP-2) is a member of the canonical TRP (TRPC) subfamily of ion channels, primarily recognized as a critical therapeutic target in parasitic nematodes such as Brugia malayi. It functions as a non-selective cation channel that mediates the influx of calcium and sodium ions, which is essential for parasite muscle contraction and locomotion. The anthelmintic drug diethylcarbamazine (DEC) acts as a direct agonist of TRP-2, inducing rapid spastic paralysis and facilitating the clearance of microfilariae and adult worms from the host. While TRP-2 is a functional and vital protein in many invertebrates and some mammals (where it is involved in pheromone sensing), it is a pseudogene in humans, which provides a molecular basis for the selective toxicity of DEC. In addition to its role in parasitology, TRP-2 orthologs in model organisms like C. elegans are involved in proprioception and steering during locomotion.

Other names

TRPC2Bm-TRP-2Transient receptor potential canonical 2TRPC-like channel 2TRP2

Agonist (Diethylcarbamazine); activates the channel to induce a rapid influx of calcium and sodium ions, leading to membrane depolarization and spastic paralysis in parasites.