Target intelligence / Profile preview

Transient Receptor Potential Channel Subfamily A Member 1 (TRPA1)

Target: TRPA1
Molecular classification: Ion channel, TRP channel, Nonselective cation channel

Overview

TRPA1 is a nonselective cation channel belonging to the TRP family. It functions as a sensor for mechanical and chemical stress, playing a crucial role in pain and chemosensation. It is activated by various irritants and inflammatory mediators, making it a target for analgesic drug development.

Other names: Wasabi receptorTRPA1 channel

Mechanism of action

Activation by various reactive chemicals or temperature changes leading to ion channel opening and subsequent neuronal depolarization and signaling.

Biological functions

Pain detectionChemosensationCold sensationOxygen concentration perceptionCough reflexItch sensationInner ear functionHeat sensitivity

Disease associations

PainInflammationNeuropathic painChronic pain

Safety considerations

Potential for off-target effects due to broad expression in sensory neurons.Altered temperature sensation.Altered pain perception.

Interacting drugs

Mustard oil (allyl isothiocyanate)

6 more in the full profile.

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