Transient receptor potential channels (TRP channels) in Brugia malayi (Bm-TRP channels)

Transient receptor potential (TRP) channels in the parasitic nematode Brugia malayi are a diverse group of cation-permeable ion channels that play critical roles in the parasite's sensory physiology and environmental adaptation (Verma et al., 2020, Molecular and Biochemical Parasitology). These channels are involved in detecting chemical, mechanical, and thermal stimuli, which are essential for the parasite to navigate the host environment, locate tissues, and maintain homeostatic functions (Kashyap et al., 2023, Parasitology International). In Brugia malayi, the causative agent of lymphatic filariasis, TRP channels such as Bm-TRP-2 and Bm-OSM-9 are expressed in sensory neurons and muscle tissues, influencing motility and reproductive behavior (WormBase ParaSite, 2024). Because these channels are vital for the survival and infectivity of the nematode and often possess structural differences from their mammalian counterparts, they are considered promising targets for the development of novel anthelmintic drugs (Choudhary et al., 2022, Experimental Parasitology). Targeting these channels could disrupt the parasite's ability to sense its environment or coordinate movement, leading to its clearance from the host.

Other names

Bm-TRPBrugia malayi TRP cation channelsFilarial TRP channelsTransient receptor potential cation channel family

Modulation of cation-permeable channels to disrupt sensory perception, environmental adaptation, and neuromuscular coordination in the parasite.