Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Transient Receptor Potential Melastatin 8 (TRPM8)
- Target
- TRPM8
- Molecular classification
- Ion channel, TRP channel, Voltage-gated ion channel
01
Overview
TRPM8 is a voltage-gated, nonselective cation channel and a member of the transient receptor potential (TRP) ion channel superfamily. It is the primary molecular sensor for environmental cold and cooling agents such as menthol. Activation leads to influx of cations, depolarization, and ultimately sensations of coolness or cold pain. It is highly expressed in sensory neurons but also found in other tissues, where its function is less well understood. TRPM8 is implicated in pain, cancer, migraine, and dry eye disease.
- Other names
- Transient receptor potential cation channel subfamily M member 8
02
Mechanism of action
Activation by cold or chemical agonists leads to Na+ and Ca2+ influx, cell depolarization, and action potential generation.
03
Biological functions
Sensory transductionThermoregulationDetection of cold temperaturesDetection of cooling agentsIon transport
04
Disease associations
Pain syndromesCold allodyniaCancerProstate cancerPancreatic cancerColon cancerBreast cancerMigraineDry eye disease
05
Safety considerations
Off-target effects in other tissues due to widespread expression.Potential for altered thermoregulation.Calcium-dependent desensitization affects drug efficacy.
06
Interacting drugs
Menthol
3 more in the full profile.
Beyond the preview
Go deeper on Transient Receptor Potential Melastatin 8 (TRPM8).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Transient Receptor Potential Melastatin 8 (TRPM8).