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Target intelligence / Profile preview
Transient receptor potential melastatin 8 protein (TRPM8)
- Target
- TRPM8
- Molecular classification
- Ion channel, Receptor
01
Overview
TRPM8 acts as the primary molecular sensor for cold temperatures in humans. It is activated by cool temperatures (typically below ~28°C) and by chemical ligands such as menthol and icilin. Upon activation, it functions as a nonselective cation channel allowing influx of Ca²⁺ and Na⁺ ions into cells. This protein plays critical roles in somatosensory perception of environmental cold and sensations associated with cooling agents like menthol.
- Other names
- Cold and menthol receptor 1CMR1Transient receptor potential cation channel subfamily M member 8
02
Mechanism of action
Activation of nonselective cation channel allowing influx of Ca²⁺ and Na⁺ ions
03
Biological functions
Somatosensory perceptionIon channel activitySignal transduction
04
Disease associations
Pain syndromesAsthmaCancer
05
Safety considerations
Potential for altered temperature sensation (cold allodynia)Respiratory conditions exacerbated by cold environments
06
Interacting drugs
Menthol
4 more in the full profile.
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