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Transient Receptor Potential Melastatin Member 8 (TRPM8)

Target: TRPM8
Molecular classification: Ion channel, TRP channel, Non-selective cation channel

Overview

TRPM8 is a member of the transient receptor potential (TRP) ion channel superfamily, specifically classified within the melastatin subfamily. It functions as a non-selective cation channel permeable to both monovalent and divalent ions, including Na(+) and Ca(2+). TRPM8 is best known as the primary molecular sensor for environmental cold in mammals and is also activated by cooling agents such as menthol and icilin.

Mechanism of action

Agonist binding leading to cation channel opening and neuronal depolarization; antagonist binding stabilizing inactive channel conformations.

Biological functions

ThermosensationCold sensationPain signalingRegulation of cell proliferationRegulation of cell migrationCore body temperature regulation

Disease associations

CancerPainDigestive Disorders

Safety considerations

Context-dependent effects on tumor biology in cancer (proliferation/migration promotion or inhibition depending on tissue/cancer type)

Interacting drugs

Menthol

3 more in the full profile.

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