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Target intelligence / Profile preview
Transient Receptor Potential Vanilloid 1 (TRPV1)
- Target
- TRPV1
- Molecular classification
- Ion channel, TRP channel, Receptor
01
Overview
Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel primarily expressed in nociceptive sensory neurons, functioning as a molecular integrator for diverse noxious stimuli like heat, acidic pH, and chemical ligands such as capsaicin. Its activation leads to pain sensations and modulates both acute and chronic pain states. Dysregulation of TRPV1 is implicated in various conditions like chronic pain, IBS, hypertension, and asthma, making it a therapeutic target. Activation can also lead to long-term synaptic depression via calcium-dependent mechanisms.
- Other names
- Capsaicin receptorVanilloid receptor 1
02
Mechanism of action
TRPV1 antagonists inhibit the activity of the TRPV1 channel, reducing pain and inflammation.
03
Biological functions
Pain perceptionNociceptionThermosensationInflammatory responseRegulation of neuropeptide releaseGastrointestinal motility regulationTemperature homeostasisSensory integration
04
Disease associations
Chronic pain syndromesIrritable bowel syndromeHypertensionAsthmaInflammation
05
Safety considerations
Side effects with antagonists remain an issuePotential for altered thermosensationPotential for cardiovascular effects
06
Interacting drugs
Capsaicin
4 more in the full profile.
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