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Target intelligence / Profile preview
Transient Receptor Potential Vanilloid 4 (TRPV4)
- Target
- TRPV4
- Molecular classification
- Ion channel, TRP channel, Vanilloid receptor
01
Overview
Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel that is permeable to Ca²⁺ and other cations. It plays key roles in various physiological processes and disease states, including osmoregulation, mechanotransduction, and pain perception. It is activated by osmotic changes, mechanical forces, chemical ligands, and warm temperatures. Mutations or dysregulation of TRPV4 are linked with several diseases, including skeletal dysplasias and neuropathies.
02
Mechanism of action
Modulation of ion channel activity
03
Biological functions
Regulation of systemic osmotic pressureVascular tone modulationLiver functionIntestinal functionRenal functionBladder functionSkin barrier integrityResponse to UV-B radiationSkeletal growthJoint functionAirway physiologyLung physiologyRetinal functionInner ear sensory functionNociceptionPain perceptionCalcium oscillations
04
Disease associations
Metatropic DysplasiaSpondylometaphyseal DysplasiaHereditary Motor & Sensory Neuropathy Type IICVascular disordersPain syndromes
05
Safety considerations
Potential for off-target effects due to widespread expressionComplex regulation and multiple activation mechanisms
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