Transient receptor potential vanilloid 4 channel (TRPV4)

Transient receptor potential vanilloid 4 channel (TRPV4) is a non-selective, calcium-permeable cation channel of the transient receptor potential (TRP) ion channel superfamily, predominantly mediating sensitivity to osmotic, mechanical, and moderate thermal stimuli[1][2][3]. It is a homotetrameric membrane protein made up of six transmembrane domains per subunit, with large cytoplasmic N- and C-terminal regions featuring ankyrin repeat domains essential for protein interactions[1][2]. TRPV4 plays a key role in systemic osmotic pressure regulation, mechanotransduction, thermosensation, vascular tone, skeletal development, and epithelial barrier function in several organs including kidney, liver, lung, skin, and the nervous system[2][3]. Dysfunction or mutations in TRPV4 are associated with a spectrum of diseases, such as inherited neuropathies, bone dysplasias, and disorders characterized by abnormal fluid homeostasis or chronic pain[3]. Pharmacological modulation of TRPV4 is under investigation for multiple therapeutic applications, though systemic effects and safety are significant considerations[1][3][5].

Other names

TRPV4Transient receptor potential cation channel subfamily V member 4VR-OACOSM9-like transient receptor potential channel member 4OTRPC4

Channel activation (agonists increase calcium influx and cellular signaling), Channel inhibition (antagonists block calcium entry and downstream effects), Modulation by osmotic, mechanical, and chemical stimuli