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Target intelligence / Profile preview
Transient receptor potential vanilloid subfamily 1 (TRPV1)
- Target
- TRPV1
- Molecular classification
- Ion channel, Transient Receptor Potential (TRP) channel, Nonselective cation channel
01
Overview
TRPV1 is a nonselective cation channel and a member of the transient receptor potential (TRP) channel family, specifically the vanilloid subfamily. It is primarily involved in the detection of noxious heat (>43°C), acidic conditions (low pH), capsaicin, and other stimuli. Activation of TRPV1 leads to pain sensation, inflammation, and other physiological responses. It is a therapeutic target for chronic pain and other diseases.
- Other names
- Capsaicin receptorVanilloid receptor 1
02
Mechanism of action
Activation leads to opening of the channel pore, allowing influx of cations (Ca2+, Na+, Mg2+), resulting in depolarization of sensory neurons and transmission of pain signals.
03
Biological functions
Pain sensation (nociception)Body temperature regulationInflammationModulation of gastrointestinal motilityCardiovascular functionRespiratory responses
04
Disease associations
Chronic painIrritable bowel syndromeHypertensionAsthmaFunctional dyspepsiaInflammation
05
Safety considerations
Desensitization with agonists may lead to altered pain perception.Blocking TRPV1 may have systemic effects due to its broad distribution.
06
Interacting drugs
Capsaicin
2 more in the full profile.
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