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Target intelligence / Profile preview
Transient receptor potential vanilloid subfamily V member 1 receptor (TRPV1)
- Target
- TRPV1
- Molecular classification
- Ion channel, Receptor
01
Overview
TRPV1 is a non-selective cation channel primarily permeable to calcium ions. It plays a central role in detection and regulation of body temperature, sensation of scalding heat (>43°C), pain (nociception), and chemical irritants such as capsaicin (from chili peppers) or allyl isothiocyanate (from mustard/wasabi). It is involved in pain transduction, thermosensation, modulation of synaptic transmission, and regulation of inflammatory responses. TRPV1 has been implicated as a therapeutic target for pain management and neuropathies.
- Other names
- Capsaicin receptorVanilloid receptor 1
02
Mechanism of action
Activation results typically lead to cation influx (Ca2+), depolarization, neurotransmitter/neuropeptide release. Antagonists/blockers targeting TRPV1 are under investigation for analgesia without affecting normal thermoregulation.
03
Biological functions
Detection and regulation of body temperatureNociceptionPain transductionThermosensationModulation of synaptic transmissionRegulation of inflammatory responses
04
Disease associations
InflammationNeuropathic painOsteoarthritisRheumatoid arthritisDiabetes-induced neuropathies
05
Safety considerations
Analgesia without affecting normal thermoregulation
06
Interacting drugs
Capsaicin
1 more in the full profile.
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