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Target intelligence / Profile preview
Transient Receptor Potential Vanilloid Subtype 1 (TRPV1)
- Target
- TRPV1
- Molecular classification
- Ion channel, Receptor, TRP channel, TRPV subfamily
01
Overview
Transient Receptor Potential Vanilloid Subtype 1 (TRPV1) is a nonselective cation channel that functions as a polymodal sensor, activated by capsaicin, noxious heat, protons, and endogenous lipids. It plays a key role in peripheral nociception, thermoregulation, and inflammation, making it a therapeutic target for various pain and inflammatory conditions.
- Other names
- Capsaicin receptorVanilloid receptor 1
02
Mechanism of action
TRPV1 is a nonselective cation channel that opens in response to various stimuli (capsaicin, heat, protons, lipids), allowing influx of cations (Ca2+, Mg2+, Na+, K+, Cs+) and subsequent neuronal depolarization and signaling.
03
Biological functions
NociceptionThermoregulationInflammation mediatorPain signalingRegulation of inflammatory mediator releaseGastrointestinal motility functionCardiovascular regulationRespiratory system function
04
Disease associations
Chronic pain syndromesFunctional dyspepsiaIrritable bowel syndromeHypertensionAsthmaInflammation
05
Safety considerations
Potential for off-target effects due to widespread expressionRisk of hyperthermia or altered pain perceptionDevelopment of tolerance to TRPV1-targeted therapies
06
Interacting drugs
Capsaicin
2 more in the full profile.
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