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Target intelligence / Profile preview
Transient Receptor Potential Vanilloid Subtype 3 (TRPV3)
- Target
- TRPV3
- Molecular classification
- Ion channel, TRP channel, Receptor
01
Overview
Transient receptor potential vanilloid subtype 3 (TRPV3) is a non-selective cation channel primarily expressed in keratinocytes and peripheral neurons. It functions as a sensor for innocuous warm temperatures and various chemical stimuli, influencing cellular signaling pathways involved in itch sensation, dermatitis, hair growth regulation, and skin regeneration. It's upregulated during injury or inflammation and considered a potential therapeutic target for treating pain and itch.
02
Mechanism of action
Inhibition of TRPV3 channel activity
03
Biological functions
Sensory perceptionCalcium homeostasisTemperature sensingChemical sensing
04
Disease associations
DermatitisPruritusPain syndromesGenetic disorders affecting skin functionInflammation
05
Safety considerations
Limited high-affinity/selective ligands available for clinical use
06
Interacting drugs
Local anesthetics
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