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Target intelligence / Profile preview
Translation elongation factor 2 (Plasmodium falciparum) (eEF2)
- Target
- eEF2
- Molecular classification
- Enzyme, Translation factor, GTPase
01
Overview
Translation elongation factor 2 (eEF2) in Plasmodium falciparum is an essential GTPase enzyme responsible for catalyzing the translocation of the ribosome along mRNA during protein synthesis. It is a validated antimalarial drug target, with inhibitors like M5717 showing potent activity by disrupting protein synthesis. Mutations in eEF2 can confer drug resistance, making it a crucial factor in drug development and deployment strategies against malaria.
- Other names
- PfeEF2PF14_0486PF3D7_1451100
02
Mechanism of action
Inhibition of eEF2 function, halting ribosomal translocation and protein synthesis
03
Biological functions
Protein synthesisRibosome translocationGTP bindingGTP hydrolysis
04
Disease associations
InfectionMalaria
05
Safety considerations
Potential for drug resistance developmentOff-target effects on host cell protein synthesis
06
Interacting drugs
M5717
07
Biomarkers
Mutations in eEF2 associated with drug resistance
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