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Target intelligence / Profile preview
Translation machinery associated 7 homolog (TMA7)
- Target
- TMA7
- Molecular classification
- Other (Coiled-coil domain-containing protein)
01
Overview
Translation machinery associated 7 homolog (TMA7) is a coiled-coil domain-containing protein implicated in cellular proliferation, migration, invasion, autophagy suppression, and apoptosis regulation, particularly in cancer cells such as laryngeal squamous cell carcinoma (LSCC)[1][3]. TMA7 is upregulated in LSCC and associated with poor prognosis, promoting cell growth and resistance to cisplatin via regulation of downstream molecules including UBA2 and the PI3K-mTOR signaling pathway[1]. Its expression is modulated by IGF2BP3-mediated m6A methylation, controlling mRNA stability and the cellular autophagic response. TMA7 interacts with UBA2, influencing SUMOylation processes and thereby affecting diverse cellular processes linked to cancer progression[1]. TMA7 is also known by several synonyms, including CCDC72 and HSPC016, and its dysfunction or dysregulation may play a role in both oncogenic and neuropsychiatric diseases[3].
- Other names
- Translation machinery-associated protein 7CCDC72HSPC016HSPC330Coiled-coil domain-containing protein 72Coiled-coil domain containing 72Translational machinery associated 7 homolog
02
Biological functions
Cell proliferationCell migrationCell invasionRegulation of autophagyApoptosis
03
Disease associations
Cancer (notably laryngeal squamous cell carcinoma)Chemotherapy resistance (e.g., cisplatin-resistance in cancer)Potential implication in neuropsychiatric disorder (schizoid personality disorder)
04
Biomarkers
Autophagy-related proteins (p62, LC3B-II/I ratio)TMA7 expression itself is a potential biomarker for prognosis and monitoring in laryngeal squamous cell carcinoma
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