Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Translationally Controlled Tumor Protein (TCTP)
- Target
- TCTP
- Molecular classification
- Other
01
Overview
Translationally controlled tumor protein (TCTP) is a highly conserved, multifunctional protein found in Plasmodium falciparum. It is involved in cell proliferation, apoptosis inhibition, and modulation of host immune responses. PfTCTP can be secreted into the bloodstream, acting as a histamine-releasing factor and interacting with host immune cells. It also binds hemin and interacts with dihydroartemisinin, potentially impacting drug action. Its role in immunopathology and drug interactions makes it a potential therapeutic target.
- Other names
- Translationally-controlled tumor protein homologPfTCTP
02
Mechanism of action
Covalent interaction with dihydroartemisinin in the presence of hemin; Histamine releasing factor
03
Biological functions
Cell proliferation controlInhibition of apoptosisImmune response modulationHistamine releaseIL-8 secretion
04
Disease associations
MalariaImmunopathologyInfectionImmune evasion
05
Safety considerations
Potential for immunopathology by mimicking mammalian HRF activityInterference with normal immune signaling pathways (B cell activation, cytokine release)Potential for immunosuppression, facilitating chronic infection
06
Interacting drugs
Dihydroartemisinin
07
Biomarkers
TCTP levels in patient serum (correlation with disease state)
Beyond the preview
Go deeper on Translationally Controlled Tumor Protein (TCTP).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Translationally Controlled Tumor Protein (TCTP).