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Translationally Controlled Tumor Protein Homolog (Plasmodium falciparum) (PfTCTP)
- Target
- PfTCTP
- Molecular classification
- Tumor Protein Homolog, Histamine-releasing factor homolog
01
Overview
The translationally controlled tumor protein homolog (TCTP) in *Plasmodium falciparum* is a conserved protein with significant roles in parasite biology and host-pathogen interactions. It is homologous to mammalian TCTP, also known as histamine-releasing factor (HRF), and has been implicated in immune modulation during malaria infection. PfTCTP is secreted by the parasite into the serum of infected individuals and can stimulate histamine release from basophils and IL-8 secretion from eosinophils. It interacts directly with dihydroartemisinin, suggesting a role in the antimalarial mechanism of action of artemisinin derivatives.
- Other names
- Malarial TCTPP. falciparum TCTP
02
Mechanism of action
Artemisinin binds covalently to PfTCTP, potentially contributing to its antimalarial activity.
03
Biological functions
Immune modulationHistamine releaseIL-8 secretionProtein binding
04
Disease associations
MalariaInfectionInflammation
05
Interacting drugs
Dihydroartemisinin
1 more in the full profile.
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