Translin (TSN)

Translin is a highly conserved DNA- and RNA-binding protein encoded by the TSN gene in humans. It forms a multimeric octameric structure that specifically recognizes conserved sequences at chromosomal translocation breakpoints, making it important in the detection and potential mediation of chromosomal rearrangements mostly in lymphoid neoplasms. Translin is abundantly expressed in the brain and testis and is involved in diverse nucleic acid processes, such as RNA metabolism (tRNA processing, RNA interference, RNA transport), transcriptional regulation, and response to DNA damage. In complex with translin-associated factor X (TRAX), it forms the C3PO complex, which facilitates endonucleolytic cleavage events during microRNA loading in the RNA-induced silencing complex (RISC). Under genotoxic stress, translin can move into the nucleus, where it binds to DNA breakpoints and may participate in chromosomal translocation events. Its functions also extend to the regulation of mRNA trafficking and integration of metabolic and behavioral responses in model organisms. Key aspects: - Not conventionally a therapeutic drug target (no drugs or mechanisms of action reported), but crucial in basic nucleic acid biology and cancer genetics. - Structure and interactions have been well-characterized, especially regarding its partnership with TRAX as the C3PO complex for microRNA processing. - Disease role is predominately as a marker or participant in chromosomal instability/translocation, rather than as a conventional target for small-molecule intervention.

Other names

BCLF-1C3PORCHF1REHF-1TBRBPTRSLNcomponent 3 of promoter of RISCrecombination hotspot associated factorRCHF-1recombination hotspot-binding proteintestis brain RNA-binding protein