Translocase of inner mitochondrial membrane 10B (TIMM10B)

Translocase of inner mitochondrial membrane 10B (TIMM10B) is an evolutionarily conserved protein found in the mitochondrial intermembrane space, functioning as a core component of the TIM22 complex. This complex is responsible for mediating the import and insertion of multi-pass transmembrane carrier proteins into the mitochondrial inner membrane, which is crucial for proper mitochondrial function. TIMM10B acts as part of a heterooligomeric chaperone assembly, facilitating the docking, translocation, and membrane integration of carrier protein precursors. Disruption or mutation of TIMM10B is associated with hereditary mitochondrial disorders such as Sengers syndrome and Mohr-Tranebjaerg syndrome, and recent literature links this protein to central nervous system diseases.

Other names

TIMM10BTIM10BTim9bFXC1Mitochondrial import inner membrane translocase subunit Tim10 BMitochondrial import inner membrane translocase subunit Tim9 BFracture Callus Protein 1Translocase of inner mitochondrial membrane 10 homolog B (yeast)