Translocase of inner mitochondrial membrane 9 (TIMM9)

Translocase of inner mitochondrial membrane 9 (TIMM9) is a mitochondrial intermembrane space chaperone protein. It is a highly conserved component of the inner mitochondrial membrane's protein import machinery, forming a hexameric complex with TIMM10 to escort hydrophobic precursor proteins to the mitochondrial inner membrane and protect them from aggregation. TIMM9 is essential for the biogenesis of various multi-pass membrane proteins, functioning as part of carrier import pathways, most notably with the TIM22 complex for metabolite carrier insertion and the sorting and assembly machinery (SAM) for outer membrane proteins[1][2][3][5]. Recent research also implicates TIMM9 as a clinically relevant biomarker associated with progression and prognosis in several cancers, such as gastric cancer; its disruption impairs mitochondrial function, cell metabolism, and cell viability[1][4][5]. No approved or investigational drugs specifically target TIMM9, and its essential role in mitochondrial protein import means it is not currently considered a conventional therapeutic target.

Other names

TIM9TIM9ATIMM9AMitochondrial import inner membrane translocase subunit Tim9Translocase of inner mitochondrial membrane 9 homologTranslocase of inner mitochondrial membrane 9 (yeast) homologMitochondrial import inner membrane translocase subunit Tim9 (yeast homolog)