Translocase of outer mitochondrial membrane 20 homolog pseudogene 3 (TOMM20P3)

TOMM20P3 is a processed pseudogene of the human TOMM20 gene, sharing 96.2% similarity with the coding TOMM20 (translocase of outer mitochondrial membrane 20) cDNA but is 5' and 3' truncated and is non-functional as a protein-coding gene. Like other processed pseudogenes, it likely arose via reverse transcription of mRNA and integration into the genome at a new location. TOMM20P3 does not code for a functional TOMM20 protein and there is no evidence that it has a biological role or therapeutic relevance. The parent TOMM20 gene encodes a mitochondrial protein import receptor, but TOMM20P3 itself is not a target for drugs, is not a receptor, and is not implicated in human diseases[2]. TOMM20P3 is distinct from the functional TOMM20 gene. TOMM20P3 is a processed, noncoding pseudogene, not a protein[2]. There are no known drugs, mechanisms of action, or disease associations for TOMM20P3. Only its parent gene, TOMM20, is involved in mitochondrial protein import and has disease links—not TOMM20P3[4][5].

Other names

TOMM20 pseudogene 3psi3Tom20TOMM20P3