Translocation protein SEC63 homolog (SEC63)

Translocation protein SEC63 homolog (SEC63) is an integral membrane protein that is a key component of the endoplasmic reticulum (ER) Sec61 translocon complex, crucial for the translocation of precursor proteins across the ER membrane[1][3][5]. SEC63 mediates both cotranslational and post-translational import of proteins into the ER and plays an auxiliary role in recognizing substrates with short, hydrophobic signal peptides[1][3][5]. It works in concert with SEC62 and HSPA5/BiP to facilitate the entry of small presecretory proteins into the SEC61 channel, enabling their passage into the ER lumen[1][5]. SEC63 is also implicated in the backward (retrograde) transport of ER proteins destined for ubiquitin-proteasome degradation[3][5]. Mutations in the SEC63 gene cause autosomal dominant polycystic liver disease and can contribute to concurrent polycystic kidney disease[2][5]. There is no current evidence that SEC63 serves as a direct therapeutic target or that any approved drugs interact specifically with this protein.

Other names

DNAJC23ERdj2PCLD2PRO2507SEC63LSEC63 protein translocation regulatorDnaJ homolog subfamily C member 23