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Target intelligence / Profile preview
Translocator Protein 18 kDa (TSPO)
- Target
- TSPO
- Molecular classification
- Transmembrane protein, Mitochondrial protein
01
Overview
The Translocator Protein 18 kDa (TSPO) is a highly conserved transmembrane protein primarily located in the outer mitochondrial membrane. It plays critical roles in cellular physiology, particularly in steroidogenic tissues and glial cells of the brain. TSPO is involved in cholesterol transport, regulation of mitochondrial functions, apoptosis, cell survival, cell proliferation, stress response, immunomodulation, and is implicated in various diseases including neurodegenerative disorders and cancers.
- Other names
- Peripheral benzodiazepine receptorPBR
02
Mechanism of action
Ligand binding modulates cholesterol transport and mitochondrial function, influencing steroidogenesis, apoptosis, and cellular stress responses.
03
Biological functions
Cholesterol transportSteroidogenesisNeurosteroid synthesisMitochondrial homeostasisRespiration regulationMembrane potential regulationEnergy balanceQuality controlMitophagy regulationApoptosis regulationCell survivalCell proliferationStress responseImmunomodulation
04
Disease associations
Neurodegenerative diseasesAlzheimer's diseaseParkinson's diseaseBrain injuryInflammationCancerColorectal cancerBrain tumorsGliomasGlioblastoma multiformeBreast cancerProstate cancerLung cancerMelanoma
05
Safety considerations
Potential for off-target effects due to widespread tissue expressionVariable binding affinity depending on genetic polymorphisms
06
Interacting drugs
PK11195
1 more in the full profile.
07
Biomarkers
Microglial activation (neuroinflammation)Cancer progression
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