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Translocon-associated protein subunit delta (SSR4)
- Target
- SSR4
- Molecular classification
- Other (part of the translocon-associated protein complex)
01
Overview
Translocon-associated protein subunit delta (SSR4) is a component of the translocon-associated protein (TRAP) complex, which is involved in the translocation of newly synthesized proteins across the endoplasmic reticulum (ER) membrane. SSR4 binds calcium to the ER membrane and helps regulate the retention of ER-resident proteins. Mutations in SSR4 can cause congenital disorders of glycosylation[2][4][5].
- Other names
- TRAPDTRAP-deltaSSR-deltasignal sequence receptor subunit deltasignal sequence receptor, deltatranslocon-associated protein deltaCDG1Y
02
Biological functions
Translocation of proteins across the endoplasmic reticulum membraneregulation of ER resident protein retentioncalcium binding to ER membrane[2][5]
03
Disease associations
Congenital disorder of glycosylation (Type Iy and Type Iic)[2]
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