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Transmembrane 9 superfamily member 2 (TM9SF2)
- Target
- TM9SF2
- Molecular classification
- Transmembrane protein, Channel or transporter (putative), Nonaspanin protein
01
Overview
Transmembrane 9 superfamily member 2 (TM9SF2) is a member of the transmembrane 9 superfamily, characterized by nine highly hydrophobic transmembrane domains and a molecular mass of roughly 76 kDa. TM9SF2 localizes to early endosomes and intracellular membranes in human cells, where it may act as a small molecule transporter or ion channel. It is involved in vesicular trafficking, cellular migration, and possibly in immune pathway regulation through formal or functional interaction with pattern recognition receptors in model organisms. TM9SF2 has been implicated as an oncogene in colorectal cancer, with elevated expression promoting cell proliferation, cell cycle progression, and anchorage-independent growth; its loss diminishes tumor fitness and correlates with a favorable clinical outcome. Although its precise biochemical function remains under investigation, TM9SF2 participates in intracellular membrane dynamics and may regulate cell adhesion and metabolic pathways connected to cancer biology.
- Other names
- Transmembrane 9 superfamily member 2TM9SF2P7676 kDa membrane proteinLnc-PCIRLncRNA Positively Correlated with Inflammatory Responsesdinucleotide oxidase disulfide thiol exchanger 3 superfamily member 2epididymis secretory sperm binding proteintransmembrane protein 9 superfamily member 2
02
Biological functions
Small molecule transportIon channel (putative)Cell cycle regulationVesicular traffickingRegulation of immune signalingControl of actin cytoskeleton
03
Disease associations
Cancer (especially colorectal cancer)Inflammation (by modulation of immune pathways)
04
Biomarkers
Overexpression in colorectal cancer and disease stagingmRNA expression levels predict prognosis (lower expression associated with favorable relapse-free survival in CRC)
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