Transmembrane 9 superfamily member 3 (TM9SF3)

Transmembrane 9 superfamily member 3 (TM9SF3) is a multi-pass transmembrane protein in the nonaspanin family, predicted to be involved in protein trafficking to and localization at cellular membranes[1][3]. It is highly expressed in several tissues and is upregulated in certain cancers, particularly scirrhous-type gastric cancer and T-cell leukemia, where it promotes cell proliferation and invasion, supporting tumor aggressiveness and making it a prognostic biomarker in these malignancies[2][4]. While not currently a direct therapeutic target, its implication in cancer biology and membrane trafficking highlights its potential relevance in oncology research and biomarker development[2].

Other names

SMBPEP70-P-isoSM-11044-binding proteindinucleotide oxidase disulfide thiol exchanger 3 superfamily member 3endomembrane protein emp70 precursor isolog

Not established; however, microRNA-1193 suppresses its expression, reducing proliferation and invasion, which implies that TM9SF3 supports these oncogenic processes when active[2]