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Target intelligence / Profile preview
Transmembrane activator and CAML interactor (TACI)
- Target
- TACI
- Molecular classification
- Receptor, Tumor Necrosis Factor Receptor Superfamily, Type III transmembrane protein
01
Overview
Transmembrane activator and CAML interactor (TACI), encoded by the TNFRSF13B gene, is a type III transmembrane protein belonging to the TNF receptor superfamily. Primarily expressed on B cells, it regulates B cell activation, differentiation, and immunoglobulin class switching by interacting with ligands like APRIL, BAFF and CAML. Defects in TACI are linked to immunodeficiencies and autoimmunity.
- Other names
- CD267CVIDCVID2RYZNTNFRSF14BIGAD2TNFRSF13B
02
Mechanism of action
TACI activates NFAT, AP-1, and NF-kappa-B through calcineurin-dependent pathways upon binding to APRIL or BAFF.
03
Biological functions
Humoral immunity regulationB cell activationB cell differentiationB cell homeostasisImmunoglobulin class switch recombinationSignal transduction
04
Disease associations
Common variable immunodeficiencySelective IgA deficiencyAutoimmunityMultiple myeloma
05
Safety considerations
Dysregulated humoral responses leading to autoimmunityPotential for antigen escape in cancer therapies targeting TACI
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