Transmembrane and coiled-coil domain-containing protein 4 (TMCO4)

Transmembrane and coiled-coil domain-containing protein 4 (TMCO4) is a human protein encoded by the TMCO4 gene on chromosome 1p36.13. TMCO4 is a multipass transmembrane protein predicted to span the endoplasmic reticulum membrane three times[1][5][7]. While its precise cellular function remains unclear, it is classified as a protein of unknown function associated with the α/β hydrolase fold family and annotated as a trispanin (three transmembrane domains). TMCO4 is expressed in various tissues, localizes predominantly to the endoplasmic reticulum, and is postulated—based on protein-protein interaction data and tissue expression patterns—to participate in protein localization, targeting, or trafficking processes[1][4]. Some data suggest that it interacts with proteins known to be implicated in cancer development, though no direct evidence currently establishes it as a drug target or with a defined disease mechanism[1][7]. TMCO4 is not recognized as a current therapeutic target and has no validated disease biomarkers, drug interactions, or significant safety concerns reported at this time[1][5][7].

Other names

DKFZp686C23231