Transmembrane and coiled-coil domain-containing protein 5A (TMCO5A)

Transmembrane and coiled-coil domain-containing protein 5A (TMCO5A) is a protein encoded by the TMCO5A gene located on chromosome 15 in humans[7][8]. It is predicted to be a structural, membrane-associated protein with localization primarily in the endoplasmic reticulum and nuclear membranes[8], and is notably expressed at high levels in the cytoplasm of spermatids, suggesting a specialized role in testicular tissue[5]. While genetic associations link the gene to prostate cancer and spastic paraplegia 11, there is no direct evidence indicating TMCO5A is a common therapeutic target, nor are there any approved drugs or mechanisms of action described for this molecule[1]. Its molecular function appears related to protein binding and possible structural maintenance, and it is not currently classified within major drug target families such as ion channels, GPCRs, or receptors.

Other names

TMCO5ATMCO5MGC35118Transmembrane and coiled-coil domain-containing protein 5ATesticular tissue protein Li 205Transmembrane and coiled-coil domains 5