Transmembrane and tetratricopeptide repeat containing 1 (TMTC1)

Transmembrane and tetratricopeptide repeat containing 1 (TMTC1) is a protein O-mannosyltransferase localized to the endoplasmic reticulum membrane, dedicated primarily to the modification of cadherin and protocadherin domains by the addition of O-linked mannose glycans onto serine or threonine residues. TMTC1, along with TMTC2–4, is distinguished from the classical dystroglycan-targeting POMT1/POMT2 enzymes by its substrate specificity. TMTC1 is critical for proper cell adhesion, migration, and invasion by modifying adhesion molecules such as integrins β1 and β4, with implications for cancer cell behavior, particularly in ovarian cancer. TMTC1 is being explored as a novel therapeutic target, and its expression level may serve as a prognostic biomarker in certain cancer types.

Other names

TMTC1Transmembrane O-mannosyltransferase targeting cadherins 1Protein O-mannosyl-transferase TMTC1TMTC1AARG99OLFFLJ31400FLJ41625transmembrane and tetratricopeptide repeat containing 1A

Not applicable (no direct interacting drugs identified). Potential mechanisms, if targeted, would likely include inhibition of O-mannosyltransferase activity, reduction of integrin modification, and subsequent decrease in cancer cell migration/invasion.