Transmembrane channel-like protein 7 (TMC7)

Transmembrane channel-like protein 7 (TMC7) is part of the TMC family of predicted multi-pass membrane proteins that share similarity with ion channels. TMC7 is predicted to function as a modulator of mechanosensitive ion channels, specifically inhibiting PIEZO2 activity in dorsal root ganglion neurons, which is relevant for sensory perception of mechanical stimuli[1][4][7]. Expression studies in mice show that TMC7 is highly and specifically expressed in testicular germ cells, most abundantly in round spermatids, where it localizes to the *cis*-Golgi apparatus and is required for acrosome biogenesis; knockout models exhibit severe defects in sperm morphology and male infertility[2]. Emerging evidence suggests TMC7 may play roles in maintaining intracellular ion and pH balance and could have additional cellular functions in membrane trafficking and homeostasis[2]. Associations with certain cancers have been reported in genetic studies, but its functional significance in human disease and as a therapeutic target remains unclear[1]. No clinically approved drugs or established biomarker roles for TMC7 are known.

Other names

FLJ21240transmembrane channel like 7TMC7