Transmembrane Domain 1 of CFTR (TMD1)

Transmembrane Domain 1 (TMD1) of the CFTR protein is a critical structural and functional component of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an ATP-binding cassette (ABC) transporter-class ion channel. TMD1, together with TMD2, forms the core transmembrane pore that allows selective passage of anions such as chloride (Cl-) and bicarbonate (HCO3-). Mutations affecting residues within or near TMD1 can disrupt proper folding, trafficking to the plasma membrane, or function of CFTR—leading to cystic fibrosis phenotypes depending on mutation severity.

Other names

CFTR TMD1TMD1

CFTR modulators (e.g., correctors, potentiators) affect the folding, trafficking, or gating of the CFTR protein, including its transmembrane domains.