Transmembrane emp24 domain-containing protein 4 (TMED4)

Transmembrane emp24 domain-containing protein 4 (TMED4) is a member of the p24/TMED/GOLD domain family, comprising type I single-pass transmembrane proteins found predominantly at the endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and Golgi apparatus. TMED4 is implicated in the formation and maintenance of secretory pathway structures and regulates the intracellular trafficking of proteins by interacting with COPI/COPII coat protein complexes. Its biological roles span secretory pathway function, Golgi structure maintenance, positive regulation of NF-kappaB signaling, and varied roles in stress response and apoptosis. Dysregulation or mutation of TMED4 and related proteins underlies several human diseases, with research highlighting their involvement in protein sorting for secretion, immune modulation, and cancer progression. TMED4 and its gene family are potential targets for future therapeutic and prognostic strategies in oncology and immune-related conditions, though no direct inhibitors or approved therapies currently exist.

Other names

TMED4ERS25p24alpha3HNLFp24a3Endoplasmic reticulum stress-response protein 25GMP25isoPutative NF-kappa-B-activating protein 156p24 family protein alpha-3Putative NFkB activating protein HNLF

For TMED family-targeting compounds in oncology and inflammation: modulation of protein trafficking and inhibition of pro-tumorigenic signaling pathways (e.g., NF-κB, PI3K/AKT, Wnt/TCF). Knockdown studies indicate impact on apoptosis and tumor proliferation.